Showing posts with label myeloma. Show all posts
Showing posts with label myeloma. Show all posts

Sunday, March 27, 2011

Multiple Myeloma


Like many others, I was shocked when I heard that Geraldine Ferraro died today. She was a key figure in the political world, but more than that, she was a beloved mother, involved teacher, lawyer, politician, and journalist. I hadn’t known she had been suffering from multiple myeloma for the past twelve years. Also, like many others, I Googled the disease to see exactly what it is.

Multiple myeloma is an incurable blood cancer. Specifically, it is cancer of the plasma cells in bone marrow.

In multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. The growth of these bone tumors makes it harder for the bone marrow to make red blood cells, white blood cells, and platelets. This causes anemia, which makes a person more likely to get infections and have abnormal bleeding. As the cancer cells grow in the bone marrow, they can cause pain and destruction of the bones. If the bones in the spine are affected, it can put pressure on the nerves, resulting in numbness or paralysis........

Saturday, March 26, 2011

Full multiple myeloma genome sequenced


For the first time, scientists have accessed the molecular causes of multiple myeloma – an aggressive, incurable blood cancer with a 5-year survival rate of 40%.

This week, several multiple myeloma genomes have been sequenced. And they reveal an assortment of mutated genes involved (that have never been suspected before) and identify chemical pathways to target in future therapies – some of which are already in development.

The disease begins in the bone marrow, where white blood cells become malignant (pictured), crowding out normal bone marrow cells and attacking solid bone. There are about 20,000 new cases in the US a year.

To map out its genetic code, researchers sequenced 38 tumor genomes from multiple myeloma patients, and then compared them with the patients’ normal DNA sequences.